The Right to be a Recalcitrant Union Member

In 1954, the United States Supreme Court considered the problem of union discipline in the case of Radio Officers\u27 Union v. NLRB. The Court clearly stated that the policy of the National Labor Relations Board (NLRB) insures the right of each employee who chooses to join a union to be a good, bad, or indifferent member. Although the validity of this phrase seems to be generally accepted, it has never been enforced as an affirmative right. The purpose of this Note is to analyze the embryonic right to be a recalcitrant union member. Since most studies have examined this area in terms of the validity of union discipline against the member, this Note will necessarily assume a different approach. The question is what affirmative rights does a member have to subvert union authority. In order to examine this question more thoroughly, the scope of this Note will be limited to an analysis of the legal developments in two areas: (I) union restrictions on employee production; and (2) union discipline for filing with the NLRB. Following this analysis, decisions of both the NLRB and the courts will be examined to determine the existence and scope of the right to be a recalcitrant union member

Exploring Protein Interactions on a Minimal Type II Polyketide Synthase Using a Yeast Two-Hybrid System

Interactions between proteins that form the ’minimal’ type II polyketide synthase in the doxorubicin producing biosynthetic pathway from Streptomyces peucetius were investigated using a yeast two-hybrid system (Y2H). Proteins that function as the so called ’chain length factor’ (DpsB) and putative transacylase (DpsD) were found to interact with the ketosynthase subunit (DpsA), which can also interact with itself. On the basis of these results we propose a head-to-tail homodimeric structure, which is consistent with previously published in vivo mutagenesis studies. No interactions were found between the acyl-carrier protein (DpsG) and any of the other constituents of the complex, however, transient interactions, not detectable using the Y2H system, cannot be discounted and warrant further investigation

Exploring Protein Interactions on a Minimal Type II Polyketide Synthase Using a Yeast Two-Hybrid System

Interactions between proteins that form the ’minimal’ type II polyketide synthase in the doxorubicin producing biosynthetic pathway from Streptomyces peucetius were investigated using a yeast two-hybrid system (Y2H). Proteins that function as the so called ’chain length factor’ (DpsB) and putative transacylase (DpsD) were found to interact with the ketosynthase subunit (DpsA), which can also interact with itself. On the basis of these results we propose a head-to-tail homodimeric structure, which is consistent with previously published in vivo mutagenesis studies. No interactions were found between the acyl-carrier protein (DpsG) and any of the other constituents of the complex, however, transient interactions, not detectable using the Y2H system, cannot be discounted and warrant further investigation

Full scale tests of the base-isolation system for an emergency hospital

The paper presents the results of some full-scale tests regarding the base-isolation system of the emergency room building of the polyclinic hospital in Palermo (Italy). This building has been recently realized and its base isolation system is characterized by double friction pendulum isolators. Static lateral pushing tests were aimed at identifying fundamental mechanical properties of the whole isolation level (e.g. friction forces and stiffness) in order to verify the agreement with the design hypotheses. Further dynamic tests provided different displacements of the isolated base followed by the instantaneous release (snap-back tests), in order to verify the effectiveness, the mechanical parameter in dynamics and re-centering capacity of the isolation system. The design of both the types of test and the respective results and interpretations are illustrated in the paper highlighting a number of issues arising when arranging such kind of investigations on full scale buildings

Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy

It is generally believed that increase in adult contractile cardiac mass can be accomplished only by hypertrophy of existing myocytes. Documentation of myocardial regeneration in acute stress has challenged this dogma and led to the proposition that myocyte renewal is fundamental to cardiac homeostasis. Here we report that in human aortic stenosis, increased cardiac mass results from a combination of myocyte hypertrophy and hyperplasia. Intense new myocyte formation results from the differentiation of stem-like cells committed to the myocyte lineage. These cells express stem cell markers and telomerase. Their number increased >13-fold in aortic stenosis. The finding of cell clusters with stem cells making the transition to cardiogenic and myocyte precursors, as well as very primitive myocytes that turn into terminally differentiated myocytes, provides a link between cardiac stem cells and myocyte differentiation. Growth and differentiation of these primitive cells was markedly enhanced in hypertrophy, consistent with activation of a restricted number of stem cells that, through symmetrical cell division, generate asynchronously differentiating progeny. These clusters strongly support the existence of cardiac stem cells that amplify and commit to the myocyte lineage in response to increased workload. Their presence is consistent with the notion that myocyte hyperplasia significantly contributes to cardiac hypertrophy and accounts for the subpopulation of cycling myocytes

FULL SCALE TESTS OF THE BASE-ISOLATION SYSTEM FOR AN EMERGENCY HOSPITAL

The paper presents the results of some full-scale tests regarding the base-isolation system of the emergency room building of the polyclinic hospital in Palermo (Italy). This building has been recently realized and its base isolation system is characterized by double friction pendulum isolators. Static lateral pushing tests were aimed at identifying fundamental mechanical properties of the whole isolation level (e.g. friction forces and stiffness) in order to verify the agreement with the design hypotheses. Further dynamic tests provided different displacements of the isolated base followed by the instantaneous release (snap-back tests), in order to verify the effectiveness, the mechanical parameter in dynamics and re-centering capacity of the isolation system. The design of both the types of test and the respective results and interpretations are illustrated in the paper highlighting a number of issues arising when arranging such kind of investigations on full scale buildings

Compensation of Nuisance Factors for Speaker and Language Recognition

The variability of the channel and environment is one of the most important factors affecting the performance of text-independent speaker verification systems. The best techniques for channel compensation are model based. Most of them have been proposed for Gaussian mixture models, while in the feature domain blind channel compensation is usually performed. The aim of this work is to explore techniques that allow more accurate intersession compensation in the feature domain. Compensating the features rather than the models has the advantage that the transformed parameters can be used with models of a different nature and complexity and for different tasks. In this paper, we evaluate the effects of the compensation of the intersession variability obtained by means of the channel factors approach. In particular, we compare channel variability modeling in the usual Gaussian mixture model domain, and our proposed feature domain compensation technique. We show that the two approaches lead to similar results on the NIST 2005 Speaker Recognition Evaluation data with a reduced computation cost. We also report the results of a system, based on the intersession compensation technique in the feature space that was among the best participants in the NIST 2006 Speaker Recognition Evaluation. Moreover, we show how we obtained significant performance improvement in language recognition by estimating and compensating, in the feature domain, the distortions due to interspeaker variability within the same language. Index Terms—Factor anal

TAS2R38 is a novel modifer gene in patients with cystic fbrosis

The clinical manifestation of cystic fbrosis (CF) is heterogeneous also in patients with the same cystic fbrosis transmembrane regulator (CFTR) genotype and in afected sibling pairs. Other genes, inherited independently of CFTR, may modulate the clinical manifestation and complications of patients with CF, including the severity of chronic sinonasal disease and the occurrence of chronic Pseudomonas aeruginosa colonization. The T2R38 gene encodes a taste receptor and recently its functionality was related to the occurrence of sinonasal diseases and upper respiratory infections. We assessed the T2R38 genotype in 210 patients with CF and in 95 controls, relating the genotype to the severity of sinonasal disease and to the occurrence of P. aeruginosa pulmonary colonization. The frequency of the PAV allele i.e., the allele associated with the high functionality of the T2R38 protein, was signifcantly lower in i) CF patients with nasal polyposis requiring surgery, especially in patients who developed the complication before 14 years of age; and ii) in CF patients with chronic pulmonary colonization by P. aeruginosa, especially in patients who were colonized before 14 years of age, than in control subjects. These data suggest a role for T2R38 as a novel modifer gene of sinonasal disease severity and of pulmonary P. aeruginosa colonization in patients with CF